General Information

  • ID:  hor005127
  • Uniprot ID:  P84666
  • Protein name:  Pyrokinin-5
  • Gene name:  NA
  • Organism:  Aptera fusca (Cape Mountain cockroach) (Giant Table Mountain cockroach)
  • Family:  pyrokinin family
  • Source:  animal
  • Expression:  Expressed in abdominal perisympathetic organs and abdominal ganglia.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aptera (genus), Epilamprinae (subfamily), Blaberidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SGDTSSQAKGMWFGPRL
  • Length:  17(1-17)
  • Propeptide:  SGDTSSQAKGMWFGPRL
  • Signal peptide:  NA
  • Modification:  T17 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P84666-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P84666-F1.pdbhor005127_AF2.pdbhor005127_ESM.pdb

Physical Information

Mass: 211059 Formula: C79H121N23O25S
Absent amino acids: CEHINVY Common amino acids: GS
pI: 9.69 Basic residues: 2
Polar residues: 7 Hydrophobic residues: 4
Hydrophobicity: -70 Boman Index: -3029
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 28.82
Instability Index: 1380 Extinction Coefficient cystines: 5500
Absorbance 280nm: 343.75

Literature

  • PubMed ID:  19257902
  • Title:  A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.